One combination engine to solve complex network biology
Indication
Modality
DiscoveryLead optimisationIND-enablingClinic
Idiopathic pulmonary fibrosisSYM-COMB001 · lead programme
mRNA + siRNA
DiscoveryLead opt.IND-enablingClinic
Liver fibrosisSYM-COMB001 · platform extension
mRNA + siRNA
DiscoveryLead opt.IND-enablingClinic
Kidney fibrosisSYM-COMB001 · platform extension
mRNA + siRNA
DiscoveryLead opt.IND-enablingClinic
Kidney fibrosisSYM-COMB002 · platform extension
mRNA + siRNA
DiscoveryLead opt.IND-enablingClinic
IPF first, then the conserved fibrosis biology across lung, liver, heart and kidney. The same combination-RNA engine applies to other multi-pathway diseases, with neurodegeneration and aging as later expansion.